SCHEMBL5083055

SCHEMBL5083055

O=C(C=Cc1cccnc1)NF

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.67
NPC1 O15118 2/20 0.67
MAPT P10636 2/20 0.67
KDM4E B2RXH2 2/20 0.67
JUN P05412 1/20 0.67
NFKB1 P19838 1/20 0.67
MAPK1 P28482 1/20 0.67
GPR55 Q9Y2T6 1/20 0.67
PFKFB3 Q16875 1/20 0.58
NAMPT P43490 9/20 0.55
KMT2A Q03164 1/20 0.55
ALDH1A1 P00352 2/20 0.54
NTSR1 P30989 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
APAF1 O14727 1/20 0.52
POLB P06746 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
CYP1A1 P04798 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12425756 0.85 RAB9A (0.69) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL2988119 0.83 RAB9A (0.67) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL2988115 0.83 RAB9A (0.67) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL10118164 0.83 RAB9A (0.67) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL28438967 0.82 ALDH1A1 (0.76) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL28431765 0.82 ALDH1A1 (0.76) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL30585556 0.81 RAB9A (0.63) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL5598850 0.80 MAPT (1.00) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL5598852 0.80 MAPT (1.00) RAB9ANPC1MAPTKDM4EJUN
SCHEMBL24091376 0.80 HDAC3 (0.64) RAB9ANPC1MAPTKDM4EJUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1664051-A4 PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS BRISTOL MYERS SQUIBB CO (US) 2008-12-31 EP disclosed
EP-1664051-A2 PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS Bristol-Myers Squibb Company (US) 2006-06-07 EP disclosed
WO-2005030144-A2 PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-04-07 WO disclosed