Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083179 | 1.00 | HTT (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| SCHEMBL5083196 | 1.00 | HTT (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL1152993 | 0.99 | HTT (0.43) | HTTDRD2HTR1ADRD1DRD5 | |
| SCHEMBL5141567 | 0.99 | HTR1A (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL1152990 | 0.99 | HTT (0.43) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL1152994 | 0.99 | HTT (0.43) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL9397536 | 0.98 | HTR1A (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL9397520 | 0.98 | HTR1A (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| Hydrochloric Acid SCHEMBL9397529 | 0.98 | HTR1A (0.44) | HTTDRD2HTR1ADRD1DRD5 | |
| SCHEMBL5080359 | 0.97 | DRD2 (0.44) | HTTDRD2HTR1ADRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266574-B1 | Piperidine compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-01-05 | — | — | EP | claimed |
| EP-0266574-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-05-11 | — | — | EP | claimed |
| WO-2008133884-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-11-06 | — | — | WO | disclosed |