Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 18/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.57 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3284 | 0.92 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| SCHEMBL3285 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| SCHEMBL28017684 | 0.78 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL541162 | 0.78 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Bromide SCHEMBL6903611 | 0.77 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL4971076 | 0.75 | SLC6A4 (0.60) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| SCHEMBL5079373 | 0.74 | SLC6A4 (0.56) | SLC6A2SLC6A4SLC6A3 | |
| (S)-Norduloxetine SCHEMBL4573573 | 0.73 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| R-Norduloxetine SCHEMBL2634027 | 0.73 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| SCHEMBL2487646 | 0.72 | SLC6A4 (0.64) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133884-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-11-06 | — | — | WO | disclosed |