Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 12/20 | 0.37 |
| ▸ | KDR | P35968 | 12/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15061682 | 0.90 | HSPB1 (0.39) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3568638 | 0.89 | HSPB1 (0.42) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL15241350 | 0.87 | HSPB1 (0.42) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3565336 | 0.84 | HSPB1 (0.38) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL2602341 | 0.82 | HSPB1 (0.45) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL306344 | 0.80 | HSPB1 (0.45) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL108759 | 0.80 | HSPB1 (0.45) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14230559 | 0.80 | HSPB1 (0.45) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3568082 | 0.80 | MET (0.51) | HSPB1MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3573701 | 0.79 | KDR (0.55) | MAPTALDH1A1MAPK1L3MBTL1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904504-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007054831-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2007-05-18 | — | — | WO | disclosed |
| EP-1781664-A1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | Methylgene, Inc. (CA) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006010264-A1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2006-02-02 | — | — | WO | disclosed |