Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL14920147 | 0.86 | LMNA (0.61) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL8841100 | 0.83 | LMNA (0.65) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL28140166 | 0.83 | LMNA (0.73) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Butyric Acid SCHEMBL8926864 | 0.82 | FFAR3 (0.65) | LMNATSHRAKR1B1FOLH1GPR84 | |
| Mercaptopropionic Acid SCHEMBL7183577 | 0.82 | ACE (0.48) | LMNAFOLH1ALDH1A1TDP1MAPT | |
| Mercaptopropionic Acid SCHEMBL6324790 | 0.82 | ACE (0.48) | LMNAFOLH1ALDH1A1TDP1MAPT | |
| Adipic Acid SCHEMBL5306019 | 0.81 | LMNA (0.61) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL25265281 | 0.80 | LMNA (0.69) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL30288555 | 0.80 | LMNA (0.69) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL28562568 | 0.80 | LMNA (0.69) | LMNATSHRNFKB1PMP22AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973874-A1 | LOW PROTONATION CONSTANT HYDROXY ACIDS | BWE I Malmö AB (SE) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007081261-A1 | LOW PROTONATION CONSTANT HYDROXY ACIDS | BWE I MALMÖ AB (SE) | 2007-07-19 | — | — | WO | disclosed |