Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | PPARD | Q03181 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL28852051 | 0.94 | SLC22A6 (0.61) | LMNATP53TSHRNFKB1PMP22 | |
| Lactic Acid SCHEMBL5709392 | 0.91 | GPR84 (0.65) | LMNATP53TSHRNFKB1PMP22 | |
| Hexanoate SCHEMBL28159215 | 0.91 | AKR1B1 (0.73) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Dodecanoate SCHEMBL8413830 | 0.89 | GPR84 (0.74) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Palmitic Acid SCHEMBL8096795 | 0.89 | GPR84 (0.74) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| 1,6-Hexanediol SCHEMBL3482818 | 0.89 | GPR84 (0.70) | LMNATP53TSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL19732970 | 0.89 | LMNA (0.48) | LMNATP53TSHRNFKB1PMP22 | |
| Dodecanoate SCHEMBL8412450 | 0.89 | GPR84 (0.74) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Stearic Acid SCHEMBL1662973 | 0.89 | GPR84 (0.74) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Myristic Acid SCHEMBL1646803 | 0.89 | GPR84 (0.74) | LMNATSHRAKR1B1SLC22A6GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038524-A2 | COCRYSTALLIZATION METHODS | SSCI, INC. (US) | 2007-04-05 | — | — | WO | disclosed |