Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ABL2 | P42684 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397796 | 0.85 | SRC (0.55) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL5086449 | 0.85 | CYP1A2 (0.36) | SRCABL1EGFRCYP1A2CYP2C19 | |
| SCHEMBL5086486 | 0.84 | IGF1R (0.39) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL5085558 | 0.78 | SRC (0.37) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL5139460 | 0.76 | SRC (0.37) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL401422 | 0.75 | SRC (0.46) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL5082715 | 0.75 | FLT3 (0.42) | SRCABL1EGFRCYP1A2CYP2C19 | |
| SCHEMBL400110 | 0.75 | SRC (0.63) | SRCRIPK2ABL1EGFRABL2 | |
| SCHEMBL5137414 | 0.75 | IGF1R (0.41) | SRCABL1EGFRCYP1A2CYP2C19 | |
| SCHEMBL400250 | 0.74 | PIK3CD (0.48) | SRCABL1EGFRIGF1RLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |