Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | ABL2 | P42684 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 7/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.36 |
| ▸ | MERTK | Q12866 | 7/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399909 | 0.86 | SRC (0.56) | SRCABL1EGFRABL2TYRO3 | |
| SCHEMBL5083287 | 0.84 | IGF1R (0.38) | SRCABL1EGFRABL2TYRO3 | |
| SCHEMBL5084774 | 0.78 | SRC (0.37) | SRCABL1EGFRABL2AXL | |
| SCHEMBL5082715 | 0.78 | FLT3 (0.42) | SRCABL1EGFRAXLTYRO3 | |
| SCHEMBL399351 | 0.78 | SRC (0.49) | SRCABL1EGFRABL2TYRO3 | |
| SCHEMBL398127 | 0.75 | RIPK2 (0.47) | SRCABL1EGFRABL2TYRO3 | |
| SCHEMBL401320 | 0.74 | PIK3CD (0.52) | SRCABL1EGFRIGF1R | |
| SCHEMBL5161210 | 0.74 | AHR (0.39) | IGF1RNOS3NOS1NOS2AHR | |
| SCHEMBL400270 | 0.74 | SRC (0.55) | SRCABL1EGFRABL2AXL | |
| SCHEMBL402582 | 0.72 | SRC (0.61) | SRCABL1EGFRABL2TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |