Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 4/20 | 0.31 |
| ▸ | ABL2 | P42684 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | LYN | P07948 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | BCR | P11274 | 2/20 | 0.31 |
| ▸ | MST1R | Q04912 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | NPM1 | P06748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400988 | 0.85 | ABL1 (0.47) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL5084774 | 0.84 | SRC (0.37) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL5085319 | 0.83 | IGF1R (0.39) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL5083287 | 0.80 | IGF1R (0.38) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL5078959 | 0.76 | LCK (0.36) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL5083828 | 0.76 | IGF1R (0.51) | IGF1RCYP3A4EGFRFGFR1KDR | |
| SCHEMBL398750 | 0.76 | IGF1R (0.41) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL400221 | 0.75 | IGF1R (0.46) | IGF1RCYP3A4ABL1EGFRKDR | |
| SCHEMBL10273338 | 0.74 | IGF1R (0.53) | IGF1RCYP3A4ABL1ABL2EGFR | |
| SCHEMBL401058 | 0.74 | IGF1R (0.53) | IGF1RCYP3A4ABL1ABL2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |