Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677631 | 0.83 | PNP (0.80) | PNPKMT2ARNASEH1DAO | |
| SCHEMBL3757599 | 0.82 | PDE4A (0.49) | PNPKMT2APDE4APDE4BPDE4C | |
| SCHEMBL8509084 | 0.78 | PNP (0.62) | PNPGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL28817761 | 0.77 | ADORA3 (0.49) | PNPKMT2APDE4APDE4BPDE4C | |
| SCHEMBL3396585 | 0.76 | PNP (0.57) | PNPGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL11133891 | 0.76 | PNP (0.57) | PNPGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3433603 | 0.76 | TSHR (0.52) | PNPKMT2AGRIA1GRIA2GRIA3 | |
| SCHEMBL3757591 | 0.76 | CYP1A2 (0.68) | DAO | |
| SCHEMBL18251 | 0.76 | PNP (0.62) | PNPPDE4APDE4BPDE4CPDE4D | |
| Guanine SCHEMBL1394087 | 0.75 | PNP (0.68) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | claimed |
| WO-2008109417-A1 | MGMT INHIBITOR COMBINATIONS FOR THE TREATMENT OF NEOPLASTIC DISORDERS | CASE WESTERN RESERVE UNIVERSITY (US) | 2008-09-12 | — | — | WO | claimed |
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | disclosed |