Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.40 |
| ▸ | INSR | P06213 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399679 | 0.78 | EGFR (0.49) | IGF1RINSR | |
| SCHEMBL5318007 | 0.76 | IGF1R (0.39) | IGF1RINSRCYP3A4 | |
| SCHEMBL5085319 | 0.76 | IGF1R (0.39) | IGF1RINSRCYP3A4 | |
| SCHEMBL400019 | 0.74 | IGF1R (0.45) | IGF1RINSRCYP3A4 | |
| SCHEMBL5139584 | 0.72 | IGF1R (0.40) | IGF1RINSRCYP3A4 | |
| SCHEMBL400570 | 0.69 | ABL1 (0.42) | IGF1RINSR | |
| SCHEMBL401016 | 0.66 | IGF1R (0.40) | IGF1RINSR | |
| SCHEMBL399340 | 0.65 | LCK (0.49) | IGF1RINSRCYP3A4 | |
| SCHEMBL399611 | 0.65 | EGFR (0.43) | IGF1RINSR | |
| SCHEMBL399750 | 0.65 | IGF1R (0.61) | IGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |