Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.39 |
| ▸ | INSR | P06213 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 4/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139584 | 0.86 | IGF1R (0.40) | IGF1RINSRCYP3A4MELKEGFR | |
| SCHEMBL399679 | 0.84 | EGFR (0.49) | IGF1RINSRABL1EGFRABL2 | |
| SCHEMBL5258556 | 0.84 | SRC (0.43) | IGF1RINSRCYP3A4ABL1EGFR | |
| SCHEMBL5086486 | 0.83 | IGF1R (0.39) | IGF1RINSRCYP3A4MELKABL1 | |
| SCHEMBL5083287 | 0.77 | IGF1R (0.38) | IGF1RINSRCYP3A4ABL1EGFR | |
| SCHEMBL5084829 | 0.76 | IGF1R (0.40) | IGF1RINSRCYP3A4 | |
| SCHEMBL5318007 | 0.75 | IGF1R (0.39) | IGF1RINSRCYP3A4 | |
| SCHEMBL400570 | 0.74 | ABL1 (0.42) | IGF1RINSRABL1EGFRABL2 | |
| SCHEMBL400019 | 0.74 | IGF1R (0.45) | IGF1RINSRCYP3A4ABL1EGFR | |
| SCHEMBL6636964 | 0.73 | IGF1R (0.53) | IGF1RINSRMELKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | claimed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |