Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 3/20 | 0.37 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142905 | 0.85 | TNK2 (0.35) | IGF1R | |
| SCHEMBL5139584 | 0.76 | IGF1R (0.40) | IGF1RCYP3A4INSR | |
| SCHEMBL5084829 | 0.76 | IGF1R (0.40) | IGF1RCYP3A4INSR | |
| SCHEMBL5085319 | 0.75 | IGF1R (0.39) | IGF1RCYP3A4INSR | |
| SCHEMBL400019 | 0.75 | IGF1R (0.45) | IGF1RCYP3A4INSR | |
| SCHEMBL399679 | 0.74 | EGFR (0.49) | IGF1RINSR | |
| SCHEMBL400570 | 0.64 | ABL1 (0.42) | IGF1RINSR | |
| SCHEMBL27678610 | 0.63 | IGF1R (0.41) | IGF1RCYP3A4 | |
| SCHEMBL27678617 | 0.61 | IGF1R (0.45) | IGF1RCYP3A4INSR | |
| SCHEMBL13541763 | 0.61 | PARP1 (0.44) | IGF1RCYP3A4INSRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007531754-A | — | — | 2007-11-08 | — | — | JP | claimed |
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | claimed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | claimed |