Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 5/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.59 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113502 | 0.85 | ERAP1 (0.75) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL1608015 | 0.85 | ERAP1 (1.00) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL5088627 | 0.82 | ERAP1 (0.83) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL7127360 | 0.77 | ERAP1 (0.75) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL4798266 | 0.77 | ERAP1 (0.75) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL7171596 | 0.77 | HSD17B3 (0.69) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL2553278 | 0.76 | HSD17B3 (0.75) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL5423355 | 0.76 | NPC1 (0.73) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL31366988 | 0.75 | HSD17B3 (1.00) | ERAP1NPC1ESR1ESR2HSD17B3 | |
| SCHEMBL591899 | 0.75 | HSD17B3 (1.00) | ERAP1NPC1ESR1ESR2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | ERAP1 2734/4885NPC1 362/4885ESR1 258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.