Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.49 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL298493 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5085194 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL2505241 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL10684637 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL3859955 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL6904643 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Decyltriphenylphosphonium SCHEMBL3654788 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL2354963 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5091833 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5086696 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |