Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.49 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL298493 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5085194 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL2505241 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL10684637 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL6904643 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Decyltriphenylphosphonium SCHEMBL3654788 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5085133 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL2354963 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5091833 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL5086696 | 1.00 | HIF1A (0.56) | HIF1ACHRNA7TRAP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238606-B1 | Methyl-Iodide-free carbonylation of methanol to acetaldehyde | EASTMAN CHEMICAL COMPANY (US) | 2016-01-19 | — | — | US | claimed |
| US-9718754-B2 | Methyl-iodide-free carbonylation of an alcohol to its homologous aldehyde and/or alcohol | EASTMAN CHEMICAL COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| US-9714206-B2 | Methyl-iodide-free carbonylation of an alcohol to its homologous aldehyde and/or alcohol | EASTMAN CHEMICAL COMPANY (US) | 2017-07-25 | — | — | US | disclosed |
| US-20160251292-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | EASTMAN CHEMICAL COMPANY (US) | 2016-09-01 | — | — | US | disclosed |
| US-20160185701-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | EASTMAN CHEMICAL COMPANY (US) | 2016-06-30 | — | — | US | disclosed |
| US-20160185700-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | EASTMAN CHEMICAL COMPANY (US) | 2016-06-30 | — | — | US | disclosed |
| US-9365479-B1 | Methyl-iodide-free carbonylation of an alcohol to its homologous aldehyde and/or alcohol | EASTMAN CHEMICAL COMPANY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9266807-B1 | Conversion of alcohols to longer chain aldehydes or alcohols | EASTMAN CHEMICAL COMPANY (US) | 2016-02-23 | — | — | US | disclosed |
| US-9238606-B1 | Methyl-Iodide-free carbonylation of methanol to acetaldehyde | EASTMAN CHEMICAL COMPANY (US) | 2016-01-19 | — | — | US | disclosed |
| US-20130199599-A1 | POLYESTER FILM, BACK SHEET FOR SOLAR CELL, AND SOLAR CELL MODULE | FUJIFILM CORPORATION (JP) | 2013-08-08 | — | — | US | disclosed |
| EP-0518973-B1 | ISOMERIZATION OF EPOXYALKENES TO 2,5-DIHYDROFURANS AND CATALYSTS COMPOSITIONS USEFUL THEREFOR | EASTMAN CHEM CO (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0624157-A1 | CONTINUOUS PROCESS FOR THE MANUFACTURE OF 2,5-DIHYDROFURANS FROM -g(g),-g(d)-EPOXYBUTENES. | EASTMAN CHEM CO (US) | 1994-11-17 | — | — | EP | disclosed |
| US-5315019-A | Continuous process for the manufacture of 2,5-dihydrofurans from γ, δ-epoxybutenes | EASTMAN CHEMICAL COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| WO-1993010111-A1 | CONTINUOUS PROCESS FOR THE MANUFACTURE OF 2,5-DIHYDROFURANS FROM η,δ-EPOXYBUTENES | EASTMAN KODAK COMPANY (US) | 1993-05-27 | — | — | WO | disclosed |
| EP-0518973-A1 | ISOMERIZATION OF EPOXYALKENES TO 2,5-DIHYDROFURANS AND CATALYSTS COMPOSITIONS USEFUL THEREFOR. | EASTMAN KODAK CO (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5082956-A | Quaternary onium iodide catalyst | EASTMAN KODAK COMPANY (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991013882-A1 | ISOMERIZATION OF EPOXYALKENES TO 2,5-DIHYDROFURANS AND CATALYSTS COMPOSITIONS USEFUL THEREFOR | EASTMAN KODAK COMPANY (US) | 1991-09-19 | — | — | WO | disclosed |
| US-4568494-A | Process for the preparation of TCNQ complexes | BAYER AKTIENGESELLSCHAFT (DE) | 1986-02-04 | — | — | US | disclosed |
| EP-0138093-A2 | Process for the preparation of TCNQ complexes | BAYER AG (DE) | 1985-04-24 | — | — | EP | disclosed |
| US-4052427-A | PROCESS FOR THE PREPARATION OF DIALKYLTIN DIHALIDES | WITCO CHEMICAL CORPORATION (US) | 1977-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185701-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | ADH1C, ADH5, ADH1A | HIF1A 3511/4885CHRNA7 690/4885TRAP1 622/4885 |
| US-20160251292-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | ADH1C, ADH5, ADH1A | HIF1A 2608/4885CHRNA7 691/4885TRAP1 750/4885 |
| US-20160185700-A1 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL | ADH1C, ADH5, ADH1A | HIF1A 2608/4885CHRNA7 691/4885TRAP1 750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.