Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 7/20 | 0.33 |
| ▸ | ABL1 | P00519 | 5/20 | 0.33 |
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | INSR | P06213 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 4/20 | 0.33 |
| ▸ | KIT | P10721 | 4/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | LYN | P07948 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399493 | 0.85 | SRC (0.50) | IGF1RSRCABL1EGFRINSR | |
| SCHEMBL5085558 | 0.84 | SRC (0.37) | IGF1RAHRALDH1A1MAPTKDM4E | |
| SCHEMBL5078959 | 0.80 | LCK (0.36) | IGF1RCYP3A4ALDH1A1MAPTKDM4E | |
| SCHEMBL5086486 | 0.80 | IGF1R (0.39) | IGF1RCYP3A4SRCABL1EGFR | |
| SCHEMBL6636964 | 0.77 | IGF1R (0.53) | IGF1RSRCABL1EGFRINSR | |
| SCHEMBL400253 | 0.77 | IGF1R (0.46) | IGF1RSRCABL1EGFRINSR | |
| SCHEMBL5085319 | 0.77 | IGF1R (0.39) | IGF1RCYP3A4SRCABL1EGFR | |
| SCHEMBL5138129 | 0.75 | IGF1R (0.46) | IGF1RSRCEGFRINSRLCK | |
| SCHEMBL402233 | 0.74 | IGF1R (0.45) | IGF1RSRCABL1EGFRINSR | |
| SCHEMBL400677 | 0.74 | PIK3CD (0.47) | IGF1RCYP3A4SRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |