Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.75 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.72 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 2/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085637 | 1.00 | MAPT (0.75) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL5433329 | 0.93 | CHRNA7 (0.78) | MAPTSMN1; SMN2ARCHRNA7MEN1 | |
| SCHEMBL5433332 | 0.93 | CHRNA7 (0.78) | MAPTSMN1; SMN2ARCHRNA7MEN1 | |
| SCHEMBL634099 | 0.87 | PDE4A (0.82) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL634098 | 0.87 | PDE4A (0.82) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL19086304 | 0.86 | ABCG2 (0.78) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL19086305 | 0.86 | ABCG2 (0.78) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL15266958 | 0.86 | SMN1; SMN2 (1.00) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL15266954 | 0.86 | SMN1; SMN2 (1.00) | MAPTSMN1; SMN2ARABCG2ACHE | |
| SCHEMBL8173909 | 0.86 | SMN1; SMN2 (0.73) | MAPTSMN1; SMN2ARABCG2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-10 | — | — | US | disclosed |
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | MAPT 4566/4885SMN1; SMN2 3973/4885AR 152/4885 |
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | ESRRG, GPER1, ESR2 | MAPT 4210/4885SMN1; SMN2 3164/4885AR 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.