Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.78 |
| ▸ | AR | P10275 | 2/20 | 0.74 |
| ▸ | CXCL12 | P48061 | 4/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.68 |
| ▸ | RELA | Q04206 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | BACE1 | P56817 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5433329 | 1.00 | CHRNA7 (0.78) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5085630 | 0.93 | MAPT (0.75) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5085637 | 0.93 | MAPT (0.75) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL25191627 | 0.91 | MEN1 (0.79) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL31233484 | 0.90 | CXCL12 (0.74) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL15006425 | 0.90 | CXCL12 (0.74) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5137913 | 0.88 | CHRNA7 (1.00) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5137911 | 0.88 | CHRNA7 (1.00) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL2052875 | 0.86 | CHRNA7 (0.82) | CHRNA7ARCXCL12PTGS1PTGS2 | |
| SCHEMBL5422585 | 0.86 | MAPT (0.80) | MEN1KMT2ATDP1BACE1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-10 | — | — | US | disclosed |
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | CHRNA7 684/4885AR 152/4885CXCL12 2220/4885 |
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | ESRRG, GPER1, ESR2 | CHRNA7 133/4885AR 143/4885CXCL12 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.