SCHEMBL5085929

SCHEMBL5085929

CC(C)(C)c1ccc(-c2ccc(C(C)(C)C)cc2-c2ccccc2)c(-c2ccccc2)c1.OP(O)Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
NPC1 O15118 1/20 0.47
PLA2G1B P04054 1/20 0.47
NFKB1 P19838 1/20 0.47
CASP3 P42574 1/20 0.47
RAB9A P51151 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ATG4B Q9Y4P1 1/20 0.47
CNR1 P21554 2/20 0.39
CNR2 P34972 2/20 0.39
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5546203 0.89 ALDH1A1 (0.57) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL26004981 0.85 ALDH1A1 (0.57) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Hydrogen Sulfide SCHEMBL28059716 0.83 ALDH1A1 (0.55) ALDH1A1NPC1PLA2G1BNFKB1CASP3
Phosphoric Acid SCHEMBL28891147 0.79 NPC1 (0.51) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL31586293 0.79 ALDH1A1 (0.44) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL13454410 0.78 ALDH1A1 (0.57) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL30222313 0.77 RXRA (0.43) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL7710060 0.77 CNR1 (0.46) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL29545640 0.77 RXRA (0.43) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL3418225 0.77 BACE1 (0.56) ALDH1A1NPC1PLA2G1BNFKB1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1554293-B1 BIS-CHELATING LIGAND AND USE THEREOF IN CARBONYLATION PROCESSES UNION CARBIDE CHEM PLASTIC (US) 2008-03-12 EP disclosed
US-7294729-B2 Bis-chelating ligand and use thereof in carbonylation processes UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2007-11-13 US disclosed
US-20060058557-A1 Bis-chelating ligand and use thereof in carbonylation processes UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC 2006-03-16 US disclosed
EP-1554293-A1 BIS-CHELATING LIGAND AND USE THEREOF IN CARBONYLATION PROCESSES UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2005-07-20 EP disclosed
WO-2004035595-A1 BIS-CHELATING LIGAND AND USE THEREOF IN CARBONYLATION PROCESSES UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 2004-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060058557-A1 Bis-chelating ligand and use thereof in carbonylation processes CBR1, CBR3, AR ALDH1A1 1153/4885NPC1 4519/4885PLA2G1B 2729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.