Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 4/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | POLG | P54098 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083668 | 0.83 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL5086028 | 0.73 | PDE2A (0.42) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5083010 | 0.71 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBABCB11 | |
| SCHEMBL14175392 | 0.70 | ABCB11 (0.42) | EGFRABCB11POLA1POLGFAP | |
| SCHEMBL5083662 | 0.69 | PDE2A (0.47) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5083002 | 0.69 | PI4KA (0.53) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL5083628 | 0.66 | ADORA2A (0.49) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL983794 | 0.66 | PI4KA (0.65) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL5179152 | 0.66 | ADORA2A (0.44) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL12948653 | 0.64 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | POLR2H, NSUN2, POLR2E | PI4KA 2684/4885PI4K2B 1893/4885PI4K2A 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.