Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Malonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL508612 | 1.00 | LDHA (0.50) | LDHASRRKDM4EKDM5CPHF8 | |
| Malonic Acid SCHEMBL508810 | 0.97 | LDHA (0.53) | LDHASRRKDM4EKDM5CPHF8 | |
| Malonic Acid SCHEMBL507804 | 0.88 | LDHA (0.64) | LDHASRRKDM4EKDM5CPHF8 | |
| Pimagedine SCHEMBL28272894 | 0.85 | TSHR (0.47) | LDHAKDM4EKDM5CPHF8KDM2A | |
| Malonic Acid SCHEMBL28390067 | 0.85 | LDHA (0.60) | LDHASRRKDM4EKDM5CPHF8 | |
| Succinic Acid SCHEMBL30862138 | 0.83 | KDM4E (0.59) | KDM4EKDM5CPHF8KDM2ACYP1A2 | |
| Pimagedine SCHEMBL507996 | 0.83 | KDM4E (0.40) | LDHASRRKDM4EKDM5CPHF8 | |
| Succinic Acid SCHEMBL28239345 | 0.83 | KDM4E (0.59) | KDM4EKDM5CPHF8KDM2ACYP1A2 | |
| Oxalic Acid SCHEMBL508424 | 0.82 | TSHR (0.44) | LDHAKDM4EKDM5CPHF8KDM2A | |
| Oxalic Acid SCHEMBL4946423 | 0.82 | TSHR (0.44) | LDHAKDM4EKDM5CPHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8425702-B2 | Precursor of an explosive composition including at least one ionic liquid and a method of desensitizing an explosive composition | ALLIANT TECHSYSTEMS INC. (US) | 2013-04-23 | — | — | US | claimed |
| US-20120024437-A1 | PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION | ALLIANT TECHSYSTEMS INC. (US) | 2012-02-02 | — | — | US | claimed |
| US-8012277-B2 | Mixture with activator; desentization melt | ALLIANT TECHSYSTEMS INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20080251169-A1 | IONIC LIQUID, A METHOD OF SYNTHESIZING AN IONIC LIQUID, A PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID, AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION | ALLIANT TECHSYSTEMS INC. (US) | 2008-10-16 | — | — | US | claimed |
| US-8425702-B2 | Precursor of an explosive composition including at least one ionic liquid and a method of desensitizing an explosive composition | ALLIANT TECHSYSTEMS INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20120024437-A1 | PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION | ALLIANT TECHSYSTEMS INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-8012277-B2 | Mixture with activator; desentization melt | ALLIANT TECHSYSTEMS INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20080251169-A1 | IONIC LIQUID, A METHOD OF SYNTHESIZING AN IONIC LIQUID, A PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID, AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION | ALLIANT TECHSYSTEMS INC. (US) | 2008-10-16 | — | — | US | disclosed |