Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.61 |
| ▸ | PRCP | P42785 | 1/20 | 0.60 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | CD44 | P16070 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11487923 | 0.98 | PNMT (0.59) | PNMTPRCPCD274HTR7 | |
| SCHEMBL915092 | 0.85 | PNMT (0.69) | PNMTPRCPCD274 | |
| Hydrochloric Acid SCHEMBL1124672 | 0.84 | PNMT (0.68) | PNMTPRCPCD274 | |
| SCHEMBL16518783 | 0.82 | PNMT (0.54) | PNMTPRCPCD274 | |
| SCHEMBL16518770 | 0.82 | PNMT (0.48) | PNMTPRCPCD274 | |
| Hydrochloric Acid SCHEMBL11487874 | 0.81 | PNMT (0.57) | PNMTPRCPCD274HTR7 | |
| SCHEMBL16784792 | 0.81 | PNMT (0.47) | PNMTPRCPCD274 | |
| SCHEMBL15272185 | 0.81 | JAK2 (0.48) | PNMTPRCPCD274 | |
| SCHEMBL14645815 | 0.80 | CD274 (0.56) | PNMTCD274HTR7CD44MAOB | |
| SCHEMBL14904918 | 0.80 | PRCP (0.66) | PNMTPRCPCD274HTR7CD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4220778-A | ANTIARRHYTHMIC, ANTIMICROBIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY | G. D. SEARLE & CO. (US) | 1980-09-02 | — | — | US | claimed |
| EP-1903028-A1 | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects | Tschollar,, Werner (CH) | 2008-03-26 | — | — | EP | disclosed |
| US-4220778-A | ANTIARRHYTHMIC, ANTIMICROBIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY | G. D. SEARLE & CO. (US) | 1980-09-02 | — | — | US | disclosed |