SCHEMBL5086592

SCHEMBL5086592

COc1c(-c2ccccc2)cc(C)cc1[Si](C)(C)C1=C(C)C=CC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 1/20 0.35
PDE4B Q07343 3/20 0.35
PDE4A P27815 2/20 0.35
PDE4C Q08493 2/20 0.35
PDE4D Q08499 2/20 0.35
METAP2 P50579 2/20 0.34
SQOR Q9Y6N5 1/20 0.33
KCNA3 P22001 1/20 0.32
ALDH1A1 P00352 6/20 0.32
CYP3A4 P08684 3/20 0.32
ADORA3 P0DMS8 1/20 0.32
IKBKB O14920 1/20 0.32
KDM4E B2RXH2 3/20 0.32
HPGD P15428 3/20 0.32
ABCG2 Q9UNQ0 1/20 0.32
MCHR1 Q99705 1/20 0.31
MAPT P10636 3/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HSD17B10 Q99714 2/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5086484 0.89 NUDT1 (0.34) NUDT1PDE4BPDE4APDE4CPDE4D
SCHEMBL5085769 0.86 NUDT1 (0.33) NUDT1PDE4BPDE4APDE4CPDE4D
SCHEMBL5086420 0.83 MAPT (0.32) METAP2ALDH1A1MAPTSMN1; SMN2
SCHEMBL5085966 0.80 ACHE (0.31)
SCHEMBL5086732 0.80 ACHE (0.31)
SCHEMBL5090806 0.79 NUDT1 (0.36) NUDT1PDE4BPDE4APDE4CPDE4D
SCHEMBL5086871 0.76 CYP3A4 (0.32) ALDH1A1CYP3A4SMN1; SMN2CYP2D6TSHR
SCHEMBL5090252 0.76 ACHE (0.31)
SCHEMBL5087069 0.74 NUDT1 (0.42) NUDT1PDE4BPDE4APDE4CPDE4D
SCHEMBL5085860 0.74 MGAM (0.31) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
EP-0963990-B1 PROCESS FOR PRODUCING CYCLOPENTADIENYL METAL SALTS AND PROCESS FOR PRODUCING CYCLOPENTADIENE DERIVATIVES BY UTILIZING THE SAME SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
US-6197990-B1 REACTING CYCLOPENTADIENE AND METAL HYDRIDE IN PRESENCE OF AMINE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-03-06 US disclosed
EP-0963990-A1 PROCESS FOR PRODUCING CYCLOPENTADIENYL METAL SALTS AND PROCESS FOR PRODUCING CYCLOPENTADIENE DERIVATIVES BY UTILIZING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-12-15 EP disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed