Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952043 | 0.88 | HTR1A (0.39) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL4951007 | 0.86 | DRD2 (0.39) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL4950383 | 0.85 | HTR1A (0.41) | DRD2HTR1AADRA2AADRA2CSLC6A2 | |
| SCHEMBL4948819 | 0.84 | HTR1A (0.41) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL4949974 | 0.83 | HTR1A (0.41) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL4950385 | 0.82 | SLC6A4 (0.41) | DRD2DRD3DRD4HTR1ASLC6A2 | |
| SCHEMBL4950204 | 0.81 | DRD2 (0.39) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL4948694 | 0.81 | HTR1A (0.43) | DRD2HTR1AADRA2AADRA2CADRA1D | |
| SCHEMBL4950234 | 0.80 | HTR1A (0.46) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL4949979 | 0.80 | SLC6A4 (0.41) | DRD2DRD3DRD4HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008526700-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1761524-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2007-03-14 | — | — | EP | claimed |
| WO-2006072430-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2006-07-13 | — | — | WO | claimed |