Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | RAD52 | P43351 | 2/20 | 0.68 |
| ▸ | BAX | Q07812 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606935 | 0.88 | KMT2A (0.68) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL6815606 | 0.87 | MEN1 (0.88) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL1305296 | 0.82 | MEN1 (0.78) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL610230 | 0.81 | MEN1 (0.73) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL6819686 | 0.81 | BAX (0.82) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL607402 | 0.80 | RAD52 (0.69) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL607109 | 0.80 | MEN1 (0.69) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL607057 | 0.80 | MEN1 (0.69) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL607210 | 0.80 | MEN1 (0.69) | KMT2AMEN1RAD52BAXLMNA | |
| SCHEMBL607023 | 0.80 | LMNA (0.73) | KMT2AMEN1RAD52BAXLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |