Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 10/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722437 | 0.90 | ROCK2 (0.44) | JAK2MEN1KMT2AROCK2 | |
| SCHEMBL5094782 | 0.82 | CCNT1 (0.42) | JAK3JAK2KDM4EMEN1PRNP | |
| SCHEMBL14947685 | 0.75 | DYRK1B (0.41) | JAK3KDM4EKMT2AKDRDYRK1B | |
| SCHEMBL5256181 | 0.73 | MAPK14 (0.41) | MEN1KMT2A | |
| SCHEMBL3258565 | 0.73 | IKBKB (0.52) | KDRDYRK1BMAPK10KCNH2 | |
| SCHEMBL5097207 | 0.72 | ROCK2 (0.45) | JAK2KDRROCK2 | |
| SCHEMBL5090990 | 0.72 | CSNK1D (0.50) | JAK2BRAF | |
| SCHEMBL3917534 | 0.72 | CYP3A4 (0.39) | JAK3KDM4EKMT2AEGFRCYP3A4 | |
| SCHEMBL3909205 | 0.72 | CYP3A4 (0.39) | JAK3KDM4EMEN1KMT2ADYRK1B | |
| SCHEMBL3253221 | 0.71 | CAMK2D (0.58) | JAK3JAK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | JAK3 90/4885JAK2 205/4885KDM4E 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.