Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | BCL6 | P41182 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090974 | 0.84 | EGFR (0.55) | EGFRITKSYKBTKAURKA | |
| SCHEMBL656063 | 0.77 | EGFR (0.69) | EGFRITKSYKAURKABCL6 | |
| SCHEMBL1034753 | 0.77 | GLO1 (0.70) | EGFRITKSYKAURKAPTK2 | |
| SCHEMBL12726559 | 0.76 | GLO1 (0.56) | EGFRITKSYKAURKAPTK2 | |
| SCHEMBL4001033 | 0.75 | EGFR (0.59) | EGFRITKSYKBTKAURKA | |
| SCHEMBL655720 | 0.73 | SYK (0.76) | EGFRITKSYKAURKA | |
| SCHEMBL656282 | 0.73 | SYK (0.76) | EGFRITKSYKAURKA | |
| SCHEMBL1036318 | 0.72 | AURKA (0.54) | EGFRITKSYKAURKAPTK2 | |
| SCHEMBL1035455 | 0.72 | SYK (0.58) | EGFRITKSYKBTKAURKA | |
| SCHEMBL1035385 | 0.72 | GLO1 (0.67) | EGFRAURKAPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | claimed |