Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 1.00 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098257 | 0.86 | ADORA1 (0.75) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL8638332 | 0.83 | ADORA1 (0.71) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL3217333 | 0.82 | ADORA1 (0.70) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL3210466 | 0.82 | ADORA1 (0.70) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL8640873 | 0.81 | ADORA1 (0.68) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL8327620 | 0.81 | ADORA1 (0.68) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL7016763 | 0.78 | ADORA1 (0.64) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL7387472 | 0.77 | ADORA1 (0.62) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| SCHEMBL21263297 | 0.76 | ADORA1 (0.61) | ADORA1NOS1NOS2ADORA3ADORA2A | |
| Hydrochloric Acid SCHEMBL9597611 | 0.76 | ADORA1 (0.60) | ADORA1NOS1NOS2ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | claimed |
| JP-9059277-A | — | — | None | — | — | JP | disclosed |
| US-8507484-B2 | Preventive and/or therapeutic agent for neutrophilic inflammatory diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-7417052-B2 | Phenylene derivative having tetrazole ring or thiazolidinedione ring | SANKYO COMPANY, LIMITED (JP) | 2008-08-26 | — | — | US | disclosed |
| US-20080004270-A1 | 3,4-Disubstituted Pyrazoles as Cyclin Dependent Kinases (Cdk) or Aurora Kinase or Glycogen Synthase 3 (Gsk-3) Inhibitors | ASTEX THERAPEUTICS LIMITED (UK) | 2008-01-03 | — | — | US | disclosed |
| US-20070213361-A1 | Preventive and/or therapeutic agent for neutrophilic inflammatory diseases | KYOWA KIRIN CO., LTD. (JP) | 2007-09-13 | — | — | US | disclosed |
| US-20070105846-A1 | Phenylene derivative having tetrazole ring or thiazolidinedione ring | RENASCIENCE CO., LTD (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1781653-A1 | 3,4-DISUBSTITUTED PYRAZOLES AS CYCLIN DEPENDENT KINASES (CDK) OR AURORA KINASE OR GLYCOGEN SYNTHASE 3 (GSK-3) INHIBITORS | Astex Therapeutics Limited (GB) | 2007-05-09 | — | — | EP | disclosed |
| EP-1724271-A1 | PREVENTIVE AND/OR THERAPEUTIC AGENT FOR NEUTROPHILIC INFLAMMATION DISEASE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-22 | — | — | EP | disclosed |
| EP-1679310-A1 | PHENYLENE DERIVATIVE HAVING TETRAZOLE RING OR THIAZOLIDINEDIONE RING | Sankyo Company, Limited (JP) | 2006-07-12 | — | — | EP | disclosed |
| US-5132216-A | Tetrazolylbiphenylmethyl-3H-imidazo 4,5-b!-pyridine derivatives produced by Streptomyces fermentation | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5102880-A | Biphenyl imidazotriazine derivatives; Hypotensive and cardiotonic agents | MERCK & CO., INC. (US) | 1992-04-07 | — | — | US | disclosed |
| US-5085992-A | Culturing striptomyces under aerobic conditions, angitensin II antagonist | MERCK & CO., INC. (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0467715-A1 | Microbial transformation process for antihypertensive products | MERCK & CO. INC. (US) | 1992-01-22 | — | — | EP | disclosed |
| EP-0456510-A1 | Antihypertensive products, a process for their preparation and pharamaceutical compositions containing them | MERCK & CO. INC. (US) | 1991-11-13 | — | — | EP | disclosed |
| US-5057522-A | Hypotensive agents | MERCK & CO., INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-5049565-A | Biosynthesis of angiotensin antagonist | MERCK & CO., INC. (US) | 1991-09-17 | — | — | US | disclosed |
| WO-1991011999-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004270-A1 | 3,4-Disubstituted Pyrazoles as Cyclin Dependent Kinases (Cdk) or Aurora Kinase or Glycogen Synthase 3 (Gsk-3) Inhibitors | CDK3, CDK1, GSK3B | ADORA1 3044/4885NOS1 2920/4885NOS2 3727/4885 |
| US-20070105846-A1 | Phenylene derivative having tetrazole ring or thiazolidinedione ring | JAK2, ABL1, CYP3A5 | ADORA1 2042/4885NOS1 2684/4885NOS2 2466/4885 |
| US-20070213361-A1 | Preventive and/or therapeutic agent for neutrophilic inflammatory diseases | MPO, MSR1, NR4A3 | ADORA1 146/4885NOS1 89/4885NOS2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.