Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 3/20 | 0.88 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BDKRB2 | P30411 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5091774 | 1.00 | DNM1 (0.88) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5091843 | 1.00 | DNM1 (0.88) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL3858577 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5087203 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5087043 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5088416 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5085433 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5091864 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5088125 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 | |
| Iodide SCHEMBL5091656 | 0.97 | DNM1 (0.94) | DNM1TSHRTHRBBDKRB2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |