Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | GSK3A | P49840 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 4/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | FAAH | O00519 | 1/20 | 0.64 |
| ▸ | MGLL | Q99685 | 1/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434811 | 1.00 | TDP1 (1.00) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL31035964 | 1.00 | TDP1 (1.00) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL9219707 | 1.00 | TDP1 (1.00) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL29263641 | 1.00 | TDP1 (1.00) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL916601 | 0.98 | TDP1 (0.96) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL30371663 | 0.93 | TDP1 (0.86) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL45050 | 0.93 | TDP1 (0.86) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL9021226 | 0.91 | TDP1 (0.82) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL24340266 | 0.88 | TDP1 (0.79) | TDP1L3MBTL1GSK3AGSK3BACHE | |
| SCHEMBL15538183 | 0.87 | TDP1 (0.77) | TDP1L3MBTL1ACHECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |