Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | ACHE | P22303 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17260659 | 0.98 | TDP1 (0.73) | TDP1L3MBTL1ACHEALDH1A1POLB | |
| SCHEMBL5093425 | 0.87 | TDP1 (1.00) | TDP1L3MBTL1ACHECASP3 | |
| SCHEMBL8434811 | 0.87 | TDP1 (1.00) | TDP1L3MBTL1ACHECASP3 | |
| SCHEMBL7954280 | 0.87 | CASP3 (0.65) | TDP1L3MBTL1ACHEALDH1A1POLB | |
| SCHEMBL31035964 | 0.87 | TDP1 (1.00) | TDP1L3MBTL1ACHECASP3 | |
| SCHEMBL9219707 | 0.87 | TDP1 (1.00) | TDP1L3MBTL1ACHECASP3 | |
| SCHEMBL29263641 | 0.87 | TDP1 (1.00) | TDP1L3MBTL1ACHECASP3 | |
| SCHEMBL24340266 | 0.86 | TDP1 (0.79) | TDP1L3MBTL1ACHEKMT2A | |
| SCHEMBL916601 | 0.85 | TDP1 (0.96) | TDP1L3MBTL1ACHEALDH1A1CASP3 | |
| SCHEMBL3792244 | 0.84 | TDP1 (0.77) | TDP1L3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875006-B1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2018-12-26 | — | — | EP | disclosed |
| US-9428465-B2 | Acid ceramidase inhibitors and their use as medicaments | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2016-08-30 | — | — | US | disclosed |
| EP-2875006-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | Fondazione Istituto Italiano Di Tecnologia (IT) | 2015-05-27 | — | — | EP | disclosed |
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-23 | — | — | US | disclosed |
| WO-2013178576-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | ASAH1, ASAH2, ACER2 | TDP1 1982/4885L3MBTL1 4382/4885ACHE 2619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.