Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106829 | 1.00 | OPRL1 (0.43) | OPRL1KDM1AKDM1BTP53GAA | |
| SCHEMBL5093446 | 1.00 | OPRL1 (0.43) | OPRL1KDM1AKDM1BTP53GAA | |
| SCHEMBL10019957 | 0.91 | OPRL1 (0.47) | OPRL1KDM1AKDM1B | |
| SCHEMBL9662965 | 0.91 | OPRL1 (0.41) | OPRL1GAAMAPT | |
| SCHEMBL9662955 | 0.91 | OPRL1 (0.41) | OPRL1GAAMAPT | |
| SCHEMBL10043505 | 0.85 | CYP2C9 (0.44) | OPRL1GAAMAPTMEN1KMT2A | |
| SCHEMBL30767882 | 0.84 | OPRL1 (0.42) | OPRL1TP53GAAMAPTMEN1 | |
| SCHEMBL29186352 | 0.84 | OPRL1 (0.42) | OPRL1TP53GAAMAPTMEN1 | |
| SCHEMBL8069369 | 0.84 | OPRL1 (0.56) | OPRL1 | |
| SCHEMBL10043508 | 0.84 | OPRL1 (0.44) | OPRL1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618101-B1 | BENZOCHROMENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-7326447-B2 | Benzochromene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-02-05 | — | — | US | disclosed |
| US-20060177603-A1 | Benzochromene derivatives | MERCK PATENT GMBH (DE) | 2006-08-10 | — | — | US | disclosed |
| EP-1618101-A2 | BENZOCHROMENE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004076438-A2 | BENZOCHROMENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-09-10 | — | — | WO | disclosed |
| US-6737125-B2 | SUCH AS 8,9-DIFLUORO-7-(4-PENTYLPHENYL)-2-PROPYL-2,3-DIHYDRO-1H -CYCLOPENTA(A)NAPHTHALENE; FOR USE IN AUTOMOBILE INTERIORS | CLARIANT FINANCE (BVI) LIMITED (VG) | 2004-05-18 | — | — | US | disclosed |
| US-20030108684-A1 | Such as 8,9-difluoro-7-(4-pentylphenyl)-2-propyl-2,3-dihydro-1H -cyclopenta(a)naphthalene; for use in automobile interiors | CLARIANT INTERNATIONAL LTD. | 2003-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030108684-A1 | Such as 8,9-difluoro-7-(4-pentylphenyl)-2-propyl-2,3-dihydro-1H -cyclopenta(a)naphthalene; for use in automobile interiors | SCO2, CYP2F1, OGFOD1 | OPRL1 971/4885KDM1A 3106/4885KDM1B 3866/4885 |
| US-20060177603-A1 | Benzochromene derivatives | SBDS, CCND2, DDT | OPRL1 2245/4885KDM1A 2540/4885KDM1B 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.