Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094604 | 1.00 | MAPT (0.39) | MAPTGAAHPGDDYRK1ADYRK3 | |
| SCHEMBL1714283 | 0.83 | GPR18 (0.43) | MAPTGAAHPGDDYRK1ADYRK3 | |
| SCHEMBL1714289 | 0.83 | GPR18 (0.43) | MAPTGAAHPGDDYRK1ADYRK3 | |
| SCHEMBL4792456 | 0.79 | MAPT (0.39) | MAPTGAAHPGDDYRK1ADYRK3 | |
| SCHEMBL4792454 | 0.79 | MAPT (0.39) | MAPTGAAHPGDDYRK1ADYRK3 | |
| Hydrochloric Acid SCHEMBL5089735 | 0.78 | CDC7 (0.40) | MAPTDYRK1ADYRK3CSNK2A1DYRK2 | |
| Hydrochloric Acid SCHEMBL5089751 | 0.78 | CDC7 (0.40) | MAPTDYRK1ADYRK3CSNK2A1DYRK2 | |
| SCHEMBL5101159 | 0.77 | MMP2 (0.39) | MAPTHPGDDYRK1ACSNK2A1DYRK2 | |
| SCHEMBL5101168 | 0.77 | MMP2 (0.39) | MAPTHPGDDYRK1ACSNK2A1DYRK2 | |
| SCHEMBL5100892 | 0.76 | CHEK1 (0.52) | MAPTGAAHPGDDYRK1ADYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | disclosed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K6, MAP3K1 | MAPT 1665/4885GAA 972/4885HPGD 1179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.