SCHEMBL5094637

SCHEMBL5094637

FC(F)(F)C(F)(F)C(F)(F)COCC1CCO1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.37
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14961520 0.91 LMNA (0.38) TSHRMAPK1
SCHEMBL14961521 0.90 LMNA (0.34) TSHRMAPK1
SCHEMBL14961545 0.86 LMNA (0.37) TSHRMAPK1
SCHEMBL14961556 0.85 LMNA (0.33) TSHRMAPK1
SCHEMBL14961591 0.85 LMNA (0.36) TSHRMAPK1
SCHEMBL1071670 0.85 TSHR (0.53) TSHRMAPK1
SCHEMBL14961589 0.84 LMNA (0.33) TSHRMAPK1
SCHEMBL7640985 0.80 TSHR (0.42) TSHRMAPK1
SCHEMBL14961482 0.80 LMNA (0.40) TSHRMAPK1
SCHEMBL9513868 0.79 TSHR (0.52) TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354985-B2 Fluorinated thermoset polyurethane elastomers prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers AEROJET ROCKETDYNE, INC. (F/K/A AEROJET-GENERAL CORPORATION) 2008-04-08 US disclosed
US-6891013-B1 Fluorinated polyurethane elastomers prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers and tetrahydrofuran AEROJET-GENERAL CORPORATION (US) 2005-05-10 US disclosed
US-20040087759-A1 Fluorinated thermoset polyurethane elastomers prepared from polyether prepolymers formed mono-substituted fluorinated oxetane monomers AEROJET ROCKETDYNE, INC. (F/K/A AEROJET-GENERAL CORPORATION) 2004-05-06 US disclosed
US-6448368-B1 HYDROXY TERMINATED POLYETHERS HAVING ASYMMETRIC PENDANT ALKOXYMETHYLENE GROUPS; HYDROPHOBIC; PREPARATION OF POLYURETHANE ELASTOMERS, THERMOSET PLASTICS AND COATINGS AEROJET-GENERAL CORPORATION 2002-09-10 US disclosed
US-6417314-B1 WEAR RESISTANCE, TEAR AND BONDING STRENGTH; COATINGS, PLASTICS AEROJET-GENERAL CORPORATION 2002-07-09 US disclosed
US-6380351-B1 FLUORINATED POLYETHERS AEROJET-GENERAL CORPORATION 2002-04-30 US disclosed
US-6037483-A CHARGING REACTION VESSEL WITH AQUEOUS MIXTURE OF MONO-SUBSTITURED OXETANE, FLUOROALCOHOL, PHASE TRANSFER CATALYST AND STRONG BASE TO FORM REACTION MIXTURE; HEATING UNTIL REACTION IS COMPLETE AEROJET-GENERAL CORPORATION (US) 2000-03-14 US disclosed
EP-0811004-A4 MONO-SUBSTITUTED FLUORINATED OXETANE MONOMERS AEROJET GENERAL CO (US) 1998-09-30 EP disclosed
US-5807977-A Polyoxetanes based on pendant perfluoroalkyl side chains such as 3-methyl-3-(2,2,2-trifluoroethoxymethyl)-oxetane to form polyethers; very low surface energy, high hydrophobicity, low glass transition temperature and low coefficient of friction AEROJET GENERAL CORPORATION (US) 1998-09-15 US disclosed
EP-0811004-A1 MONO-SUBSTITUTED FLUORINATED OXETANE MONOMERS AEROJET-GENERAL CORPORATION (US) 1997-12-10 EP disclosed
US-5668250-A Polyether coprepolymers formed from mono-substituted fluorinated oxetane monomers and tetrahydrofuran AEROJET-GENERAL CORPORATION (US) 1997-09-16 US disclosed
US-5668251-A Preparation of co-prepolymers from mono-substituted fluorinated monomers and tetrahydrofuran AEROJET-GENERAL CORPORATION (US) 1997-09-16 US disclosed
US-5654450-A THERMOPLASTIC RESIN INTERMEDIATES; TEAR STRENGTH, ADHESION AEROJET-GENERAL CORPORATION (US) 1997-08-05 US disclosed
US-5650483-A PREPARING A SOLUTION OF A CATALYST, AN INITIATOR AND A SOLVENT, CONTACTING SOLUTION WITH A SECOND SOLUTION CONTAINING FLUORINATED OXETANE MONOMER(S) AND CONTROLLING THE TEMPERATURE OF THE MIXTURE AEROJET-GENERAL CORPORATION (US) 1997-07-22 US disclosed
WO-1996021657-A1 MONO-SUBSTITUTED FLUORINATED OXETANE MONOMERS AEROJET-GENERAL CORPORATION (US) 1996-07-18 WO disclosed