Ciaftalan

Ciaftalan

SCHEMBL5094879

O[GaH2].c1ccc2c(c1)-c1nc-2nc2[nH]c(nc3nc(nc4[nH]c(n1)c1ccccc41)-c1ccccc1-3)c1ccccc21.c1ccc2c(c1)-c1nc-2nc2[nH]c(nc3nc(nc4[nH]c(n1)c1ccccc41)-c1ccccc1-3)c1ccccc21

nearest known ligand 0.46

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
RECQL P46063 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
THRB P10828 1/20 0.46
APEX1 P27695 1/20 0.46
BLM P54132 1/20 0.46
CA5A P35218 1/20 0.38
MAPK1 P28482 2/20 0.34
POLB P06746 3/20 0.34
KDM4E B2RXH2 2/20 0.34
GAA P10253 2/20 0.34
ALDH1A1 P00352 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
GLA P06280 1/20 0.34
MAPT P10636 1/20 0.34
IDO1 P14902 1/20 0.34
TDO2 P48775 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ciaftalan SCHEMBL74723 1.00 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL4543771 0.98 MEN1 (0.45) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL293303 0.98 MEN1 (0.45) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL3166730 0.96 MEN1 (0.44) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL29360952 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL1728179 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
SCHEMBL813083 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL29356273 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL5795179 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB
Ciaftalan SCHEMBL15816 0.94 MEN1 (0.46) MEN1KMT2ARECQLTDP1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7468231-B2 Imaging members XEROX CORPORATION (US) 2008-12-23 US disclosed
US-20060177751-A1 Imaging members XEROX CORPORATION 2006-08-10 US disclosed
US-6756169-B2 LOW SURFACE ENERGY SINGLE PHOTOGENERATING LAYER DISPERSED WITH SUBMICRON SIZE POLYTETRAFLUROETHYLENE XEROX CORPORATION 2004-06-29 US disclosed
US-20040018440-A1 Imaging members XEROX CORPORATION 2004-01-29 US disclosed
US-6656650-B1 Imaging members XEROX CORPORATION 2003-12-02 US disclosed