Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 14/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768386 | 0.81 | MAPK8 (0.55) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL5094147 | 0.80 | MAPK8 (0.56) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL3817313 | 0.75 | MAPK8 (0.47) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL5096420 | 0.74 | DDB1 (0.38) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL5095753 | 0.73 | MAPK8 (0.72) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL5095751 | 0.73 | MAPK8 (0.72) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL3814433 | 0.72 | MAPK8 (0.50) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL3820942 | 0.72 | CCNT1 (0.44) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL3823223 | 0.71 | CDK1 (0.53) | CDK1CCNB1CCNT1CDK9CDK7 | |
| SCHEMBL14193418 | 0.71 | MAPK8 (0.79) | CDK1CCNB1CCNT1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | claimed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | CDK1 203/4885CCNB1 916/4885CCNT1 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.