Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | USP19 | O94966 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817313 | 0.78 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5094147 | 0.77 | MAPK8 (0.56) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3820942 | 0.77 | CCNT1 (0.44) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL8196491 | 0.76 | MAPK8 (0.67) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5102560 | 0.76 | MAPK8 (0.67) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3814504 | 0.76 | MAPK8 (0.67) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL14768386 | 0.76 | MAPK8 (0.55) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5096419 | 0.72 | CDK1 (0.51) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL14193418 | 0.71 | MAPK8 (0.79) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5090552 | 0.70 | MAPK8 (0.70) | MAPK8MAPK9MAPK10MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102194-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008068171-A9 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-07-16 | — | — | WO | disclosed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |