Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090593 | 0.95 | PLA2G2A (0.46) | PLA2G2AAXLPPARAPDGFRAKDR | |
| SCHEMBL5093351 | 0.94 | PLA2G2A (0.48) | PLA2G2AMAPTTDP1L3MBTL1RAB9A | |
| SCHEMBL5088628 | 0.93 | PLA2G2A (0.44) | PLA2G2AAXLMAPTTDP1L3MBTL1 | |
| SCHEMBL5088461 | 0.92 | PLA2G2A (0.43) | PLA2G2AMAPTALDH1A1 | |
| SCHEMBL5098634 | 0.91 | PLA2G2A (0.47) | PLA2G2AMAPTTDP1L3MBTL1RAB9A | |
| SCHEMBL5093321 | 0.90 | PLA2G2A (0.45) | PLA2G2AALDH1A1PPARADHODHKDM4E | |
| SCHEMBL5088597 | 0.90 | PLA2G2A (0.45) | PLA2G2AMAPTTDP1L3MBTL1RAB9A | |
| SCHEMBL5093341 | 0.90 | MRGPRX4 (0.46) | PLA2G2AMAPTRAB9APDGFRAKDR | |
| SCHEMBL5141934 | 0.89 | FFAR4 (0.45) | PLA2G2AAXLL3MBTL1PPARAMEN1 | |
| SCHEMBL5097666 | 0.88 | PPARA (0.42) | TDP1L3MBTL1ALDH1A1PPARADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |