Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.58 |
| ▸ | GCGR | P47871 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104532 | 0.94 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104620 | 0.80 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5097818 | 0.80 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104603 | 0.79 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL14033804 | 0.78 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104332 | 0.78 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5097762 | 0.78 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5104338 | 0.78 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5097718 | 0.77 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL5139713 | 0.77 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-20060252810-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | LAUFER STEFAN | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252810-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | IL2, TPMT, IFNG | MAPK14 3913/4885MAPK13 3863/4885MAPK12 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.