Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.56 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104601 | 0.85 | ALDH1A1 (0.62) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL3534751 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL3537670 | 0.80 | ALDH1A1 (0.58) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5098003 | 0.79 | GAA (0.50) | ALDH1A1MAPTL3MBTL1POLBLMNA | |
| SCHEMBL7515290 | 0.78 | MAPT (0.58) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL20623078 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL26482569 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL7805753 | 0.76 | MAPT (0.62) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5104609 | 0.76 | NPC1 (0.52) | ALDH1A1MAPTL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL5098076 | 0.76 | MAPT (0.62) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427683-B2 | c-fms kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1812425-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047479-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |
| US-20050131022-A1 | C-fms kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131022-A1 | C-fms kinase inhibitors | FLT3, FES, FGR | ALDH1A1 4568/4885MAPT 296/4885L3MBTL1 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.