Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 16/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.47 |
| ▸ | DRD2 | P14416 | 13/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104402 | 0.91 | ALDH1A1 (0.44) | DRD3KCNH2DRD2HRH3HRH1 | |
| SCHEMBL4769845 | 0.85 | DRD3 (0.65) | DRD3KCNH2DRD2 | |
| SCHEMBL4770301 | 0.79 | DRD3 (0.55) | DRD3KCNH2DRD2 | |
| SCHEMBL5110978 | 0.78 | HRH3 (0.44) | DRD3KCNH2DRD2HRH3 | |
| SCHEMBL4773455 | 0.77 | DRD3 (0.67) | DRD3KCNH2DRD2 | |
| SCHEMBL4763300 | 0.77 | DRD3 (0.46) | DRD3KCNH2DRD2HRH3 | |
| SCHEMBL5097933 | 0.77 | NPC1 (0.49) | DRD3KCNH2DRD2HRH3 | |
| SCHEMBL5112149 | 0.77 | ALDH1A1 (0.45) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL4772428 | 0.77 | DRD3 (0.59) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL4767832 | 0.76 | DRD3 (0.68) | DRD3KCNH2DRD2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |