Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804659 | 0.86 | P2RX7 (0.57) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| SCHEMBL1803988 | 0.85 | P2RX7 (0.58) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| SCHEMBL1804722 | 0.84 | P2RX7 (0.56) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837101 | 0.84 | P2RX7 (0.56) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1803211 | 0.83 | P2RX7 (0.54) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| SCHEMBL1802966 | 0.83 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL1806664 | 0.82 | P2RX7 (0.59) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| SCHEMBL1801178 | 0.82 | P2RX7 (0.59) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| Trifluoroacetic Acid SCHEMBL3836980 | 0.82 | P2RX7 (0.52) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 | |
| SCHEMBL1805205 | 0.82 | P2RX7 (0.58) | P2RX7L3MBTL1EPHX2KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408065-B2 | P2X7 receptor antagonists and their use | ASTRAZENECA AB (SE) | 2008-08-05 | — | — | US | disclosed |