Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 3/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647648 | 0.89 | ADORA3 (0.67) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL5106357 | 0.88 | NQO1 (0.64) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL1649113 | 0.86 | NQO1 (0.76) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL1647642 | 0.83 | CYP2C9 (0.75) | NQO1CYP2C9HSD17B10VKORC1KDM4E | |
| SCHEMBL6827896 | 0.79 | VKORC1 (0.54) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL7356247 | 0.79 | NQO1 (0.76) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL14034056 | 0.79 | NQO1 (0.67) | NQO1CYP2C9HSD17B10VKORC1KDM4E | |
| SCHEMBL1649135 | 0.78 | NQO1 (0.57) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL5100246 | 0.77 | VKORC1 (0.77) | NQO1ADORA3CYP2C9HSD17B10VKORC1 | |
| SCHEMBL7350666 | 0.77 | NQO1 (0.86) | NQO1CYP2C9HSD17B10VKORC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | DRUZGALA PASCAL | 2008-09-11 | — | — | US | claimed |
| US-7145020-B2 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS (US) | 2006-12-05 | — | — | US | claimed |
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | DRUZGALA PASCAL | 2008-09-11 | — | — | US | disclosed |
| US-20070129429-A1 | Materials And Methods For Treating Coagulation Disorders | ARYX THERAPEUTICS, INC. | 2007-06-07 | — | — | US | disclosed |
| US-7145020-B2 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS (US) | 2006-12-05 | — | — | US | disclosed |
| US-6864279-B2 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS (US) | 2005-03-08 | — | — | US | disclosed |
| US-20040220258-A1 | Materials and methods for treating coagulation disorders | ESPERO BIOPHARMA, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20030199573-A1 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS, INC. | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199573-A1 | Materials and methods for treating coagulation disorders | CES1, F2, CYP3A5 | NQO1 249/4885ADORA3 2300/4885CYP2C9 24/4885 |
| US-20080221204-A1 | Materials and Methods for Treating Coagulation Disorders | CES1, F2, CYP3A5 | NQO1 249/4885ADORA3 2300/4885CYP2C9 24/4885 |
| US-20070129429-A1 | Materials And Methods For Treating Coagulation Disorders | CES1, F2, CYP3A5 | NQO1 249/4885ADORA3 2300/4885CYP2C9 24/4885 |
| US-20040220258-A1 | Materials and methods for treating coagulation disorders | CES1, F2, CYP3A5 | NQO1 249/4885ADORA3 2300/4885CYP2C9 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.