Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 3/20 | 0.54 |
| ▸ | NQO1 | P15559 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825815 | 0.93 | VKORC1 (0.61) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5112793 | 0.86 | VKORC1 (0.71) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5106976 | 0.85 | VKORC1 (0.73) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5112806 | 0.85 | VKORC1 (0.74) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL1647660 | 0.84 | VKORC1 (0.76) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5100246 | 0.83 | VKORC1 (0.77) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5100298 | 0.82 | VKORC1 (0.78) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL5106357 | 0.81 | NQO1 (0.64) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL1647648 | 0.80 | ADORA3 (0.67) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 | |
| SCHEMBL6827699 | 0.80 | CYP2C9 (0.57) | VKORC1NQO1ADORA3CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383756-A1 | COUMARIN DERIVATIVES TO BE USED AS ANTICOAGULANTS | Arxy Therapeutics (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002085882-A1 | COUMARIN DERIVATIVES TO BE USED AS ANTICOAGULANTS | ARXY THERAPEUTICS (US) | 2002-10-31 | — | — | WO | disclosed |