Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1598470 | 0.90 | LMNA (0.49) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL14075584 | 0.79 | LMNA (0.53) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL12706294 | 0.76 | LMNA (0.49) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL14494341 | 0.76 | LMNA (0.49) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL30046017 | 0.74 | LMNA (0.56) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL1599534 | 0.74 | LMNA (0.56) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL29691288 | 0.74 | LMNA (0.53) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL14638384 | 0.74 | LMNA (0.56) | LMNANAMPTKMT2AGRNSORT1 | |
| SCHEMBL14075595 | 0.74 | LMNA (0.57) | LMNANAMPTKMT2AGRNSORT1 | |
| Hydrochloric Acid SCHEMBL5012063 | 0.73 | LMNA (0.51) | LMNANAMPTKMT2AGRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080086007-A1 | 2-(Pyrazole-1-Yl)Pyridine Derivative | SHIONOGI & CO., LTD. (JP) | 2008-04-10 | — | — | US | disclosed |
| EP-1829870-A1 | 2-(PYRAZOL-1-YL)PYRIDINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080086007-A1 | 2-(Pyrazole-1-Yl)Pyridine Derivative | MRPL21, CYP1A2, PDXK | LMNA 2987/4885NAMPT 2469/4885KMT2A 3012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.