Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316001 | 0.81 | KMT2A (0.65) | CYP2C19CYP1A2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7505473 | 0.80 | ALDH1A1 (0.70) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL15315085 | 0.80 | TSHR (0.60) | CYP2C19CYP1A2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4000768 | 0.79 | SMN1; SMN2 (0.58) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3011208 | 0.79 | SMN1; SMN2 (0.58) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7955066 | 0.79 | SMN1; SMN2 (0.58) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL11438039 | 0.78 | SMN1; SMN2 (0.57) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8627153 | 0.76 | CYP1A2 (0.56) | CYP2C19CYP1A2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7321401 | 0.76 | KMT2A (0.59) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4588624 | 0.76 | KMT2A (0.59) | CYP2C19SMN1; SMN2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080033175-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2008-02-07 | — | — | US | disclosed |
| US-7297795-B2 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| EP-1660453-A2 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-QUINOLINECARBONITRILES | Wyeth Holdings Corporation (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| WO-2005019201-A2 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-QUINOLINECARBONITRILES | WYETH HOLDINGS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050043537-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2005-02-24 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | CYP2C19 3888/4885CYP1A2 4402/4885SMN1; SMN2 2766/4885 |
| US-20080033175-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | BTF3, PTMS, BCAT2 | CYP2C19 2542/4885CYP1A2 841/4885SMN1; SMN2 4781/4885 |
| US-20050043537-A1 | Process for preparation of 4-amino-3-quinolinecarbonitriles | BTF3, PTMS, BCAT2 | CYP2C19 2542/4885CYP1A2 841/4885SMN1; SMN2 4781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.