Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23775498 | 0.82 | HTR2A (0.51) | HTR2AHTR2CTMEM97SIGMAR1THRB | |
| SCHEMBL6251264 | 0.79 | PRKAA2 (0.56) | HTR2AHTR2CPRKAA2THRBKCNH2 | |
| SCHEMBL5278050 | 0.78 | HTR2A (0.63) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL2548790 | 0.77 | HTR2A (0.75) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Hydrochloric Acid SCHEMBL27499109 | 0.77 | HTR2A (0.62) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL2226775 | 0.77 | GAA (0.64) | HTR2AHTR2CPOLBGAAKDM4E | |
| SCHEMBL5099895 | 0.76 | HTR2A (0.55) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL7027668 | 0.76 | FABP1 (0.65) | HTR2AHTR2CGAAMAPT | |
| SCHEMBL5106532 | 0.75 | PRKAA2 (0.64) | HTR2AHTR2CPRKAA2KCNH2 | |
| SCHEMBL15109199 | 0.74 | HTR2A (0.77) | HTR2AHTR2CDRD4SLC6A2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329749-B2 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GESELLSCHAFT (DE) | 2008-02-12 | — | — | US | claimed |
| WO-2002057256-A9 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-12-08 | — | — | WO | claimed |
| EP-1366039-B1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-09-07 | — | — | EP | claimed |
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GMBH (DE) | 2004-04-22 | — | — | US | claimed |
| EP-1366039-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GmbH (DE) | 2003-12-03 | — | — | EP | claimed |
| WO-2002057256-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | claimed |
| US-7329749-B2 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |
| WO-2002057256-A9 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-12-08 | — | — | WO | disclosed |
| EP-1366039-B1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GMBH (DE) | 2004-04-22 | — | — | US | disclosed |
| EP-1366039-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GmbH (DE) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002057256-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | TPH2, HTR2C, HTR1A | HTR2A 5/4885HTR2C 2/4885DRD4 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.