Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 14/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.63 |
| ▸ | TSHR | P16473 | 12/20 | 0.63 |
| ▸ | LMNA | P02545 | 11/20 | 0.63 |
| ▸ | USP2 | O75604 | 10/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104541 | 0.91 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4864864 | 0.89 | CYP1A2 (0.67) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5103948 | 0.88 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5102199 | 0.88 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4864380 | 0.87 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5107541 | 0.83 | ACHE (0.69) | CYP1A2CYP3A4KMT2AMEN1BCHE | |
| SCHEMBL5103792 | 0.83 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5104646 | 0.83 | ACHE (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5104358 | 0.81 | APP (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4868186 | 0.81 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | claimed |
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | GPR119, GCKR, GLP1R | CYP1A2 528/4885CYP3A4 441/4885CYP2D6 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.