Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099977 | 0.88 | AHR (0.39) | AHRMAPKAPK2PTGS2PIK3CAMTOR | |
| SCHEMBL7111884 | 0.82 | MAPKAPK2 (0.35) | MAPKAPK2PTGS2PIK3CAMTORPDK1 | |
| SCHEMBL7112263 | 0.82 | AHR (0.39) | AHRMAPKAPK2PTGS2PIK3CAMTOR | |
| SCHEMBL7116087 | 0.82 | SMN1; SMN2 (0.42) | MAPKAPK2PTGS2PDK1PDK2PDK3 | |
| SCHEMBL620562 | 0.80 | AHR (0.58) | AHRSRD5A1SRD5A2GAAMAPT | |
| SCHEMBL5106538 | 0.80 | MAOA (0.42) | MAPKAPK2PTGS2PTGS1MEN1CYP3A4 | |
| SCHEMBL7114536 | 0.79 | PTGER4 (0.35) | MAPKAPK2PTGS2PTGS1MEN1CYP3A4 | |
| SCHEMBL14098102 | 0.78 | MAPKAPK2 (0.36) | MAPKAPK2PTGS2PTGS1MEN1CYP3A4 | |
| SCHEMBL14098211 | 0.78 | ALOX5 (0.38) | PTGS2PIK3CAMTORPIK3CGMEN1 | |
| SCHEMBL14138738 | 0.78 | MAPKAPK2 (0.44) | MAPKAPK2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-7410997-B2 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SULSAN KAISHA, LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| EP-1182200-B1 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | NIPPON SUISAN KAISHA LTD (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-20040127713-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD. | 2004-07-01 | — | — | US | disclosed |
| US-6700013-B2 | O-BROMOPHENYLACETIC ACID DERIVATIVE CHEMICAL INTERMEDIATE; SMOOTH MUSCLE RELAXANTS, ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | NIPPON SUISAN KAISHA, LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| US-20030220360-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD., A JAPAN CORPORATION | 2003-11-27 | — | — | US | disclosed |
| US-6602898-B1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | NIPPON SUISAN KAISHA, LTD. (JP) | 2003-08-05 | — | — | US | disclosed |
| EP-1182200-A9 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Nippon Suisan Kaisha, Ltd. (JP) | 2002-05-22 | — | — | EP | disclosed |
| EP-1182200-A1 | TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Nippon Suisan Kaisha, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220360-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | HRH2, HRH1, HRH4 | AHR 41/4885MAPKAPK2 3008/4885PTGS2 312/4885 |
| US-20040127713-A1 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof | HRH2, HRH1, HRH4 | AHR 41/4885MAPKAPK2 3008/4885PTGS2 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.